研究業績


ヘルスフード科学講座　小山智之
原著論文
19. Karatungiols A and B, two novel antimicrobial polyol compounds, from the symbiotic marine dinoflagellate Amphidinium sp.
K. Washida, T. Koyama, K. Yamada, M. Kita and D. Uemura
Tetrahedron Lett. 47, 2521-2525 (2006).
18. Hepatoprotective effect of the edible thorny oyster Spondylus varius on carbon tetrachloride-induced liver injury in mice.
T. Koyama, R. Chounan, D. Uemura, K. Yamaguchi, and K. Yazawa
Biosci. Biotechnol. Biochem. 70(3), 729-731 (2006).
17. Feeding attractants for the muricid gastropod Drupella cornus, a coral predator.
M. Kita, M. Kitamura, T. Koyama, T. Teruya, H. Matsumoto, Y. Nakano and D. Uemura
Tetrahedron Lett. 46(49), 8447-8622 (2005).
16. Corallinafuran and corallinaether, novel toxic compounds from crustose coralline red algae.
M. Kitamura, T. Koyama, K. Nakano and D. Uemura
Chem. Lett. 34(9), 1272-1273 (2005).
15. Symbioimine and neosymbioimine, amphoteric iminium metabolites from the symbiotic marine dinoflagellate Symbiodinium sp.
M. Kita, N. Ohishi, K. Washida, M. Kondo, K. Yamada, T. Koyama and D. Uemura,
Bioorg. Med. Chem. 13, 5253-5258 (2005).
14 Cardiovascular effects and lethality of venom from nematosysts of the box-jellyfish Chiropsalmus quadrigatus (Habu-kurage) in anaesthetized rats.
K. Noguchi, M. Sakanashi, T. Matsuzaki, J. Nakasone, M. Sakanashi, T. Koyama, N. Hamadate, M. Sakanashi and M. Sakanashi,
Toxicon 45, 519-526 (2005).
13. Free radical scavenging and hepatoprotective actions of the medicinal herb, Crassocephalum crepidioides from the Okinawa Islands.
Y. Aniya, T. Koyama, C. Miyagi, M. Miyahira, C. Inomata, S. Kinoshita and T. Ichiba,
Biol. Pharm. Bull. 28(1), 19-23 (2005).
12. Symbioimine exhibiting inhibitory effect of osteoclast differentiation, from the symbiotic marine dinoflagellate Symbiodinium sp.
M. Kita, M. Kondo, T. Koyama, K. Yamada, T. Matsumoto, K. Lee, J. Woo, and D. Uemura,
J. Am. Chem. Soc. 126(15), 4794-4795 (2004).
11. Nakiterpiosin and nakiterpiosinone, novel cytotoxic C-nor-D-homosteroid from the Okinawan Sponge Terpios hoshinota.
T. Teruya, S. Nakagawa, T. Koyama, H. Arimoto, M. Kita and D. Uemura,
Tetrahedron 60, 6989-6993 (2004).
10. Nakiterpiosin, a novel cytotoxic C-nor-D-homosteroid from the Okinawan sponge Terpios hoshinota.
T. Teruya, S. Nakagawa, T. Koyama, H. Arimoto, M. Kita and D. Uemura,
Tetrahedron Lett. 44, 5171-5173 (2003).
9. Haemodynamic effects of the crude venom from nematocysts of the box-jellyfish (Habu-kurage), Chiropsalmus quadrigatus in anaesthetized rabbits.
T. Koyama, K. Noguchi, M. Sakanashi, T. Matsuzaki, J. Nakasone, M. Sakanashi, and M. Sakanashi,
Toxicon 41(5), 621-631 (2003).
8. Effects of diltiazem on in vitro cardiovascular actions of crude venom obtained from Okinawan box-jellyfish (Habu-kurage), Chiropsalmus quadrigatus.
M. Sakanashi, T. Matsuzaki, J. Nakasone, T. Koyama, M. Sakanashi, I. Kukita, and M. Sakanashi,
Anaesth. Intens. Care. 30, 570-577 (2002).
7. Terpiodiene: A novel tricyclic alcohol from the Okinawan sponge Terpios hoshinota.
T. Teruya, S. Nakagawa, T. Koyama, K. Suenaga, and D. Uemura,
Chem. Lett. 31(1), 38-39 (2002).
6. Arachidonic acid and alpha-linolenic acid, feeding attractants for the crown-of-thorns sea star Acanthaster planci, from the sea urchin Toxopneustes pileolus.
T. Teruya, K. Suenaga, T. Koyama, Y. Nakano and D. Uemura,
J. Exp. Mar. Biol. Ecol. 266(2), 123-134 (2001).
5. Comparison of hemodynamic responses to cilnidipine and nicardipine in an experimental model of acute congestive heart failure.
K. Noguchi, T. Matsuzaki, T. Koyama, T. Itomine and M. Sakanashi,
Clin. Exp. Pharmacol. Physiol. 25, 541-547 (1998).
4. Analysis for sites of anticoagulant action of plancinin, a new anticoagulant peptide isolated from the starfish Acanthaster planci, in the blood coagulation cascade.
T. Koyama, K. Noguchi, Y. Aniya and M. Sakanashi,
G. Pharmacol. 31, 277-282 (1998).
3. Beneficial hemodynamic effects of nicorandil in a canine model of congestive heart failure: comparison with nitroglycerin and cromakalim.
K. Noguchi, T. Matsuzaki, Y. Ojiri, T. Koyama, J. Nakasone and M. Sakanashi,
Fund. Clin. Pharmacol. 12, 270-278 (1998).
2. Acetaminophen-derived activation of liver microsomal glutathione S-transferase of rats.
M. Yonamine, Y. Aniya, T. Yokomakura, T. Koyama, T. Nagamine, and H. Nakanishi,
Jpn. J. Pharmacol. 72, 175-181 (1996).
1. Purification of anticoagulant factor from the spine venom of the crown-of-thorns starfish, Acanthaster planci.
I. Karasudani, T. Koyama, S. Nakandakari, and Y. Aniya,
Toxicon 34, 871-879 (1996).
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ヘルスフード科学講座　小山智之
tskoyama@s.kaiyodai.ac.jp
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